Iron backed by science. Scientifically superior absorption with less side effects

Established in 1997, Colorado Biolabs is the original company to bring heme iron polypeptide to market. We remain the only manufacturer of Heme Iron Polypeptide (HIP) in the U.S. and pride ourselves on utilizing solely bovine USDA edible materials for safety and traceability. Through two decades of research and refinement, our Proferrin® products deliver a high-quality product with purity that is third party tested with every batch*.

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Dr. Wag Shore

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Dr. Kelly Parcell

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Mike Friedman, Olympic Cyclist

High-Quality Iron for Your Family's Wellness

Whether you are an athlete, a woman looking to maintain healthy iron levels during her cycle, or one of the many other people who are looking for a safe, effective way to support healthy iron levels, Proferrin® can help. Studies show that Proferrin® can also be effective during pregnancy3 when taken as directed by your doctor*.

Our Products

Proferrin® ES

Why You Should Choose Proferrin® ES

Proferrin® ES is the original heme iron supplement. It contains Heme Iron Polypeptide, a natural form of iron found in meat. Compared to other forms of iron, it has 10-23x higher absorption 1, can be taken with or without food, coffee, calcium, or Vitamin C, and is not affected by PPIs*.

Proferrin® Clear

Why You Should Choose Proferrin® Clear

Proferrin® Clear is our all-natural option for those that don’t prefer tablets or color dyes. It contains the same amount of heme iron as Proferrin® ES; however, it comes in a dye-free gel capsule form rather than a tablet. It is a simple yet effective product with only four ingredients.

Proferrin® Forte

Why You Should Choose Proferrin® Forte

Proferrin® Forte was designed for those who need a little more iron and can benefit from the folic acid provided by our unique formula. It comes in a coated tablet form like Proferrin® ES but contains 1.5 mg more of heme iron than either ES or Clear, for a total of 12 mg, and it also contains 1000mcg (1667 mcg DFE) of folic acid.

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Heme Iron Content

10.5 mg

12 mg

10.5 mg

Folic Acid

1 mg





Smaller pill (dye-free capsule)

Easy-swallow coating

References: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

1) Nam, Tae-Sik & Shim, Ji & Kim, Byung-Ju & Rah, Young & kwang hyun, Park & Kim, Seon-Young & Mun, Eun-Gyeng & Jeong, Young-Ju & Han, Myung-Kwan & Cha, Youn-Soo & Chae, Soo-Wan & Im, Mie-Jae & Kim, Uh-Hyun. (2006). “Clinical Study on the Iron Absorption from
Heme-Iron Polypeptide and Nonheme-Iron*.” Nutritional Sciences The Korean Nutrition Society. 9. 295-300.

2) Ndegwa, Sarah, and Raymond Banks. (2007). “Heme Iron Polypeptide (Proferrin®) versus Oral and Injectable Iron Products for the Treatment of Anemia.”

3) Abdelazim IA, Abu-Faza M, Elbiaa AA, Othman HS, Alsharif DA, Elsawah WF. Heme iron polypeptide (Proferrin®-ES) versus iron saccharate complex (ferrosac) for treatment of iron deficiency anemia during pregnancy. Acta Med Int 2017;4:56-61

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Heme Iron
(ferrous sulfate, ferrous gluconate, iron bisglycinate)

High absorption rate

15%-35% absorption

Less than 5% absorption

Can be taken with or without food

Absorption is not affected by vitamin C intake

Absorption is not blocked by calcium

Absorption is not blocked by coffee or tea

Absorption is not affected by PPIs

Less than a 2% chance of GI side effects (i.e. nausea, gas, constipation)

Want to learn more about the differences between Proferrin® and non-heme iron?

If you’re new to the Proferrin® brand or just want to learn more about the research behind our products, click the button below!

Physician Partnership

Because of the high absorption, low side effects, and ease of use, many physicians have chosen to partner with us to offer Proferrin to their patients. If you are interested in learning more, check out our Physician Information page!
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